Effect of Beta-Endorphin and Beta-Endorphin-Like Peptide Immunorphin on the Growth of Human Leukemic Cells in vitro
Malkova NV*/**, Krasnova SB**, Navolotskaya EV**, Zargarova TA**, Prasolov VS*
*Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; **Branch of M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
Russ. J. Immunol. 2002, October, 7 (3), 239-244The influence of beta-endorphin and immunorphin on human leukemic cell growth in vitro was studied. It was shown that both peptides increase the growth of T-lymphoblastoid cells in a dose-dependent manner. The effect of these peptides on the (3)H-thymidine incorporation into T-lymphoblastoid cell line Jurkat was not reversed by the antagonist of opioid receptor naloxone. Interestingly, these peptides had no effect on B-lymphoblastoid and promyelocyte cell growth, however they enhance (3)H-thymidine incorporation into myeloid cell lines.