Features of Immune Status in Patients with Tetralogy of Fallot during Operative Treatment

Dudarev IV

Regional Hospital & Scientific Research Institute of Clinical Immunology, Rostov State Medical University, Rostov-on-Don, Russia

Russ. J. Immunol. 2001, December, 6 (4), 405-411

Twenty six patients with tetralogy of Fallot at the age from 1 to 3 years old were examined. All examined patients required surgical correction of heart defect and were operated under conditions of artificial circulation. All patients were in a status of relative compensation or subcompensation. The level of a saturation SaO(2) among patients with tetralogy of Fallot in peripheral arterial blood was equal to 66.277.2%. The purpose of work was to study the dynamics of immunological parameters in patients with tetralogy of Fallot in the postoperative period. The complex dynamic study of immune status was carried out to resolve such a task. Identification of membrane markers of peripheral blood immunocompetent cells was made by flow cytofluometry with the usage of monoclonal antibodies to antigens: CD3, CD4, CD5, CD8, CD11b, CD16, CD22, CD25, CD45 RA, HLA DR, CD95. The parameters were determined in dynamics: before operation, on the 7th, the 30th day and after 3 months after operation. Stabilization of parameters of the immune status among patients with tetralogy of Fallot, has been found in the postoperative period and was maintained within 3 months. Apparently it may be due to normalization of cardiohemodynamics, and as a consequence the stabilization of metabolic processes, undoubtedly, rendering modulating effects on immune system of children. However remaining failure of functional activity of immunocompetent cells is the reason to the usage of immunocorrection therapy with the purpose of faster stabilization of immune disbalance.

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