Ivanovo State Medical Academy, Ivanovo, Russia
Russ. J. Immunol. 2000, April 15, 5 (1), 63-70.
In children (aged 3-8 years old) with minimal cerebral dysfunction the immune status was studied before and after cerebrolysin administration in the dosage of 1 ml per 10 kg of child’s weight, intramuscularly, within one month. The cerebrolysin administration resulted in an increase in the level of CD19+ cells with a simultaneous normalization of serum IgG and IgA levels. The count of CD4+ lymphocytes has risen. Normalization of a relative count of CD16+ cells (NK) was noted after cerebrolysin therapy. Expression of activation markers (CD25+ and HLA DR) in total population of lymphocytes parallelly changed, achieving the parameters of the control group without any changes in expression of CD95+ molecule. Under the cerebrolysin influence the activation mainly of T helpers could be observed in vitro.