Shabaldin AV, Glushkov AN
Kemerovo Scientific Center, Siberian Branch of Russian Academy of Sciences, Kemerovo Russia
Russ. J. Immunol. 1999, April 15, 4 (1), 9-18.
The development of immunopathology in prenatal and postnatal periods has been studied with special refer to immune interaction character in mother-fetus system and inherited HLA DR genes. The immune variant of customary recurrent abortion has been shown to be associated with the HLA DR2 and HLA DR6 genes, with poor immune recognition of fetus HLA antigens and absence of serum suppressive factors in women. The distorted immune interactions with HLA antigens in the mother-fetus system are transformed into the neonatal period as purulent-septic diseases and hemolytic disease of the newborns. The development of immunopathology, the maturation of main immunity parameters and postvaccinal immune response in the first-year-infants are associated with the inherited HLA DR genes.