Glushkov AN, Anosova TP, Anosov MP, Zheleznova LYa, Nebesnaya NG
Institute of Coal, Siberian Branch of Russian Academy of Sciences, Kemerovo, Russia
Russ. J. Immunol. 1997, April 15, 2 (1), 49-54.
Some interrelations between generation of antibodies to polycyclic aromatic hydrocarbons and immunogenic capacity of carcinoembryonic antigen were studied in patients with mammary and gastrointestinal types of cancer. IgM, IgG and IgA antibodies to polycyclic aromatic hydrocarbons were determined by a method of enzyme-linked immunosorbent assay. Immunogenic activity of carcinoembryonic antigen was evaluated by its ability to form circulating immune complexes. It was found that in patients with mammary cancer, generations of IgA to polycyclic aromatic hydrocarbons was interrelated with high immunogenic form of carcinoembryonic antigen, whereas IgG synthesis was associated with its low immunogenic form. Alternatively, patients with gastro-intestinal cancer did not exhibit any appreciable interrelation between generation of immunoglobulins and immunogenic activity of carcinoembryonic antigen.