Central Research Laboratory, Physician Postgraduate Training Institute, Novokuznetsk, Russia
Russ. J. Immunol. 1996, December 15, 1 (1), 55-60.
Native and modified with ammonium ions alpha2-macroglobulin forms exhibit similar abilities to influence proliferative activity and secretion of immunoglobulins in cultures of human blood mononuclear cells in vitro. Effects of modified with ammonium ions alpha2-macroglobulin were more significant than those of native alpha2-macroglobulin. Revealed properties of native alpha2-macroglobulin could be conditioned by a partial modification of its structure with endogenous proteinases or cytokines, some of which were shown to be common affinants for both forms.